Takashi INOUE

Prof Dr Takashi Inoue was graduated from Tokyo Dental College at 1978. He became assistant professor in Department of Pathology, Tokyo Dental College and completed his Ph.D. at 1983. Between 1983 and 1985 he worked as visiting Associate Professor of MRC program Dental Implantology in Faculty of Dentistry, University of Toronto. He received is national license of doctor of oral pathologist in 1990 and started working as associate professor Department of Pathology in Tokyo Dental College in 1991. In 1994 he started to work as visiting research associate in Department of Biomaterial in School of Dentistry, University of Alabama at Birmingham. Dr Inoue became professor in Department of Clinical Pathophysiology, Tokyo Dental College in 2001, received his national license of basic implant in 2003. Prof Inoue was assigned as director of International Relations in 2004 and director of Oral Health Science Center in2009 at Tokyo Dental College. He continued his studies as Dean of Postgraduate School of Tokyo Dental College in 2010, Visiting Professor of Tokyo University of Science in 2012, Director of Chiba Hospital of Tokyo Dental College in 2013, Councilor of FDI in 2014 and Vice president of Japanese Dental Science Federation in 2015. Since 2016 Prof Inoue has been working as Dean of Dental Hygienist School of Tokyo Dental College.


Dental implant with functional periodontal tissues using either artificial protein and stem cells


The use of dental implants has grown extensively over the last 30 years due to increased demand for dental care. Dental implants contact many different tissues, the implant material must have optimum surface compatibility with the host epithelial tissue, connective tissue, and bone tissue. In addition, dental implants, which are partially exposed to the oral cavity, must remain biofilm-free. Such materials can be created under well-controlled conditions by modifying the surfaces that contact those tissues. “Tissue-compatible implants,” which are compatible with all host tissues, must integrate with bone tissue, easily form hemidesmosomes, and prevent biofilm formation. Our current study showed that the peri-implant epithelium was similar to oral epithelium, but the peri-implant epithelium maintains a lower capacity to act as a proliferative defense mechanism than does the junctional epithelium. The rough and grooved surfaced implant contributes to a more rapid cell migration in greater quantities and this mean that rough surfaced implant make possible osseointegration in abundant cellular elements during normal wound healing.


Recently, surface modification of materials such as titanium and/or zirconium have become an important area in medical engineering. Although a number of chemical and physical methods for such surface modification have already been established, there is still an urgent need to establish a method whereby titanium surfaces may be “biologically” modified for use in regenerative medicine. I have employed the recently established “motif-programming” methodology to “biologically” modify titanium and zirconium surfaces, and have created interfacing artificial proteins that endowed those surfaces with cell-binding activity. Further more, I am going to talk about artificial periodontal ligament around the dental implant using embryonic dental sac tissues and alveolar bone regeneration using stem cells and iPS.